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Correlations of disease severity outcome measures in inclusion body myositis

Published:August 23, 2022DOI:https://doi.org/10.1016/j.nmd.2022.08.005

      Highlights

      • IBMFRS strongly correlated to Rankin, MMT12, and timed get up (|r| =0.78-0.81).
      • IBMFRS modestly correlated to mOBFRS, FVC and grip/pinch (r = 0.41-0.66).
      • Timed get up strongly correlated with MMT12 (r = -0.76).
      • Several IBM outcome measures showed significant correlations with one another.

      Abstract

      This study aimed to evaluate the correlation between various outcome measures used to assess disease severity and progression in inclusion body myositis (IBM) clinical trials. A cross-sectional study, involving 51 IBM patients meeting the European Neuromuscular Center (ENMC) 2011 criteria for clinically defined or probable IBM, was completed at the University of California, Irvine. Clinical details, demographic data, and functional data including timed get up (TGU), manual muscle testing, hand grip, pinch dynamometry, as well as IBM functional rating scale (IBMFRS), modified Rankin score, forced vital capacity (FVC), and modified ocular bulbar facial respiratory scale (mOBFRS) were collected on all patients. Descriptive statistics and Pearson's r correlation were performed to analyze the data. Age of the patient did not correlate with any of the outcome measures. Greater severity of IBMFRS scores correlated with longer disease duration as well as greater severity for FVC, strength outcomes, TGU, modified Rankin, and mOBFRS. Additionally, TGU strongly correlated with muscle strength measurements, modified Rankin, and mOBFRS. mOBFRS moderately correlated with IBMFRS, muscle strength, FVC, TGU and modified Rankin score. We demonstrate moderate to strong correlations among the disease severity outcome measures in this study.

      Keywords

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