Highlights
- •Quality of life is poorer in adults with muscular dystrophy (MD) than controls.
- •Psychological parameters considerably impact quality of life in adults with MD.
- •Physical function has some impact on quality of life in adults with MD.
- •Greater attention to psychological parameters should be given for adults with MD.
Abstract
The impacts of potentially treatable psychological parameters on quality of life are
relatively unreported in adults with Facioscapulohumeral, Becker and Limb-girdle muscular
dystrophy. The purpose of this study was to compare quality of life, psychological
parameters, and physical function between adults with muscular dystrophy and controls,
and to examine relationships among these parameters in muscular dystrophy. Twenty-one
adults with muscular dystrophy (n = 7 Becker, n = 8 Facioscapulohumeral, n = 6 Limb-girdle) and ten age-matched controls participated. Outcome measures were
health-related quality of life, depressive symptoms, trait anxiety, self-esteem, physical
self-worth and six-minute walk distance. Quality of life scores were lower in the
muscular dystrophy groups than the control (p < .05). Depressive symptoms had the greatest association with quality of life in
the Mental Health domain (r= −0.89, p < .001). Depressive symptoms also had the most associations with quality of life
(7 of 10 domains), followed by trait anxiety (6 of 10 domains), physical self-worth
(5 of 10 domains), self-esteem (4 of 10 domains) and six-minute walk distance (3 of
10 domains). Psychological parameters and, to a lesser extent, physical function impact
quality of life in muscular dystrophy. This study provides a rationale to include
psychological assessment and treatment within muscular dystrophy healthcare.
Keywords
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Article info
Publication history
Published online: January 18, 2021
Accepted:
January 12,
2021
Received in revised form:
January 8,
2021
Received:
October 22,
2020
Identification
Copyright
© 2021 Elsevier B.V. All rights reserved.
