Abstract
In this cross-sectional study we assessed the prevalence of hyperCKemia, defined as
persistent CK values ⩾210 U/L in women, ⩾400 U/L in men <50 years and ⩾280 U/L in men ⩾50 years (reference values according to the Nordic Reference Interval Project).
Blood samples were obtained from 12,828 participants in the 6th survey of The Tromsø
Study. We identified 686 (5.3%) individuals with incidentally elevated CK. After a
standardized control test, 169 persons (1.3%) had persistent hyperCKemia, i.e. 69.9%
normalization. Use of statins or other causes of hyperCKemia were detected in 78 individuals
(46.2%), giving a prevalence of “idiopathic hyperCKemia” of 0.71%. CK variation was
highest in younger men and in females between 60 and 69 years. This study has identified persistent hyperCKemia in 1.3% of the normal population,
and demonstrates the importance of performing controlled CK analyses, also in those
with identified risk factors.
Keywords
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Article info
Publication history
Accepted:
April 8,
2011
Received in revised form:
April 1,
2011
Received:
March 9,
2011
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
