Isolated inflammatory myopathy with rimmed vacuoles presenting with dropped head
Received 12 May 2009; received in revised form 13 August 2009; accepted 19 August 2009.
Abstract
We describe an unusual case of inflammatory myopathy with rimmed vacuoles associated with dropped head syndrome. Muscle biopsy in our patient revealed variations in fiber size with fiber necrosis and regeneration, accompanied by many rimmed vacuoles and areas of endomysial cell infiltration. Electron microscopy demonstrated autophagic vacuoles and tubulofilamentous inclusions. This myopathy can cause dropped head syndrome in a subgroup of patients.