Neuromuscular Disorders
Volume 19, Issue 11 , Pages 788-796 , November 2009

Gait analysis using accelerometry in dystrophin-deficient dogs

  • Inès Barthélémy

      Affiliations

    • Laboratoire de Neurobiologie, Ecole Nationale Vétérinaire d’Alfort, 94704 Maisons-Alfort, France
  • ,
  • Eric Barrey

      Affiliations

    • INRA, Génétique animale et biologie intégrative, 78352 Jouy-en-Josas, France
    • Unité de biologie intégrative des adaptations à l’effort, INSERM 902, 91000 Evry, France
  • ,
  • Jean-Laurent Thibaud

      Affiliations

    • Laboratoire de Neurobiologie, Ecole Nationale Vétérinaire d’Alfort, 94704 Maisons-Alfort, France
  • ,
  • Ane Uriarte

      Affiliations

    • Laboratoire de Neurobiologie, Ecole Nationale Vétérinaire d’Alfort, 94704 Maisons-Alfort, France
  • ,
  • Thomas Voit

      Affiliations

    • Institut de Myologie, Université Paris 6 UMR S974, Inserm U974, CNRS UMR 7215, GH Pitié-Salpêtrière, 75651 Paris Cedex 13, France
  • ,
  • Stéphane Blot

      Affiliations

    • Laboratoire de Neurobiologie, Ecole Nationale Vétérinaire d’Alfort, 94704 Maisons-Alfort, France
    • Corresponding Author InformationCorresponding authors. Tel.: +33 143967171; fax: +33 143967089 (S. Blot), tel.: +33 142165880; fax: +33 142165881 (J.-Y. Hogrel).
  • ,
  • Jean-Yves Hogrel

      Affiliations

    • Institut de Myologie, Université Paris 6 UMR S974, Inserm U974, CNRS UMR 7215, GH Pitié-Salpêtrière, 75651 Paris Cedex 13, France
    • Corresponding Author InformationCorresponding authors. Tel.: +33 143967171; fax: +33 143967089 (S. Blot), tel.: +33 142165880; fax: +33 142165881 (J.-Y. Hogrel).

Received 14 April 2009 ,Revised 10 July 2009 ,Accepted 31 July 2009.

References 

  1. Valentine BA, Cooper BJ, de Lahunta A, O’Quinn R, Blue JT. Canine X-linked muscular dystrophy. An animal model of Duchenne muscular dystrophy: clinical studies. J Neurol Sci. 1988;88:69–81
  2. Yiu EM, Kornberg AJ. Duchenne muscular dystrophy. Neurol India. 2008;56:236–247
  3. Sharp NJ, Kornegay JN, Van Camp SD, et al. An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy. Genomics. 1992;13:115–121
  4. Kerkis I, Ambrosio CE, Kerkis A, et al. Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic?. J Transl Med. 2008;6:35
  5. Sampaolesi M, Blot S, D’Antona G, et al. Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs. Nature. 2006;444:574–579
  6. Yue Y, Ghosh A, Long C, et al. A Single Intravenous Injection of Adeno-associated Virus Serotype-9 Leads to Whole Body Skeletal Muscle Transduction in Dogs. Mol Ther. 2008;16:1944–1952
  7. Yokota T, Lu QL, Partridge T, et al. Efficacy of systemic morpholino exon-skipping in duchenne dystrophy dogs. Ann Neurol. 2009;65:667–676
  8. Kornegay JN, Bogan DJ, Bogan JR, et al. Contraction force generated by tarsal joint flexion and extension in dogs with golden retriever muscular dystrophy. J Neurol Sci. 1999;166:115–121
  9. Thibaud JL, Monnet A, Bertoldi D, Barthelemy I, Blot S, Carlier PG. Characterization of dystrophic muscle in golden retriever muscular dystrophy dogs by nuclear magnetic resonance imaging. Neuromuscul Disord. 2007;17:575–584
  10. Shimatsu Y, Yoshimura M, Yuasa K, et al. Major clinical and histopathological characteristics of canine X-linked muscular dystrophy in Japan, CXMDJ. Acta Myol. 2005;24:145–154
  11. Armand S, Mercier M, Watelain E, Patte K, Pelissier J, Rivier F. A comparison of gait in spinal muscular atrophy, type II and Duchenne muscular dystrophy. Gait Posture. 2005;21:369–378
  12. D’Angelo MG, Berti M, Piccinini L, et al. Gait pattern in Duchenne muscular dystrophy. Gait Posture. 2008;29:36–41
  13. Gaudreault N, Gravel D, Nadeau S. Evaluation of plantar flexion contracture contribution during the gait of children with Duchenne muscular dystrophy. J Electromyogr Kinesiol. 2007;19:e180–e186
  14. Patte K, Pelissier J, Benaim C, Laassel EM, Guibal C, Echenne B. Gait analysis in Duchenne muscular dystrophy. Ann Readapt Med Phys 2000;43:57–68.
  15. Sutherland DH, Olshen R, Cooper L, et al. The pathomechanics of gait in Duchenne muscular dystrophy. Dev Med Child Neurol. 1981;23:3–22
  16. Jeannet PY, Ganea R, Spehrs-Ciaffi V, Goemans NM, Aminian K, Paraschiv-Ionescu A. Gait pattern assessment over 200 m in Duchenne muscular dystrophy (DMD). Neuromuscul Disord. 2008;18:739
  17. Mercuri E, Mayhew A, Muntoni F, et al. Towards harmonisation of outcome measures for DMD and SMA within TREAT-NMD; Report of three expert workshops: TREAT-NMD/ENMC Workshop on outcome measures, 12th–13th May 2007, Naarden, The Netherlands; TREAT-NMD Workshop on outcome measures in experimental trials for DMD, 30th June–1st July 2007, Naarden, The Netherlands; Conjoint Institute of Myology TREAT-NMD Meeting on physical activity monitoring in neuromuscular disorders, 11th July 2007, Paris, France. Neuromuscul Disord. 2008;18:894–903
  18. American Thoracic Society . ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166:111–117
  19. Boddy KN, Roche BM, Schwartz DS, Nakayama T, Hamlin RL. Evaluation of the six-minute walk test in dogs. Am J Vet Res. 2004;65:311–313
  20. Allen K, DeCamp CE, Brambilla PG, Bahns M. Kinematic gait analysis of the trot in healthy mixed breed dogs. Vet Comp Orthop Traumatol. 1994;7:148–153
  21. Clements DN, Owen MR, Carmichael S, Reid SW. Kinematic analysis of the gait of 10 labrador retrievers during treadmill locomotion. Vet Rec. 2005;156:478–481
  22. Gillette RL, Zebas CJ. A two-dimensional analysis of limb symmetry in the trot of Labrador retrievers. J Am Anim Hosp Assoc. 1999;35:515–520
  23. Poy NS, DeCamp CE, Bennett RL, Hauptman JG. Additional kinematic variables to describe differences in the trot between clinically normal dogs and dogs with hip dysplasia. Am J Vet Res. 2000;61:974–978
  24. Evans R, Horstman C, Conzemius M. Accuracy and optimization of force platform gait analysis in Labradors with cranial cruciate disease evaluated at a walking gait. Vet Surg. 2005;34:445–449
  25. Kapatkin AS, Arbittier G, Kass PH, Gilley RS, Smith GK. Kinetic gait analysis of healthy dogs on two different surfaces. Vet Surg. 2007;36:605–608
  26. Lopez MJ, Quinn MM, Markel MD. Evaluation of gait kinetics in puppies with coxofemoral joint laxity. Am J Vet Res. 2006;67:236–241
  27. Madore E, Huneault L, Moreau M, Dupuis J. Comparison of trot kinetics between dogs with stifle or hip arthrosis. Vet Comp Orthop Traumatol. 2007;20:102–107
  28. Fanchon L, Valette JP, Sanaa M, Grandjean D. The measurement of ground reaction force in dogs trotting on a treadmill: an investigation of habituation. Vet Comp Orthop Traumatol. 2006;19:81–86
  29. Lascelles BD, Roe SC, Smith E, et al. Evaluation of a pressure walkway system for measurement of vertical limb forces in clinically normal dogs. Am J Vet Res. 2006;67:277–282
  30. Brebner NS, Moens NM, Runciman JR. Evaluation of a treadmill with integrated force plates for kinetic gait analysis of sound and lame dogs at a trot. Vet Comp Orthop Traumatol. 2006;19:205–212
  31. Kavanagh JJ, Menz HB. Accelerometry: a technique for quantifying movement patterns during walking. Gait Posture. 2008;28:1–15
  32. Auvinet B, Berrut G, Touzard C, et al. Reference data for normal subjects obtained with an accelerometric device. Gait Posture. 2002;16:124–134
  33. Auvinet B, Bileckot R, Alix AS, Chaleil D, Barrey E. Gait disorders in patients with fibromyalgia. Joint Bone Spine. 2006;73:543–546
  34. Dingwell JB, Cusumano JP, Sternad D, Cavanagh PR. Slower speeds in patients with diabetic neuropathy lead to improved local dynamic stability of continuous overground walking. J Biomech. 2000;33:1269–1277
  35. Paquet JM, Auvinet B, Chaleil D, Barrey E. Analysis of gait disorders in Parkinson’s disease assessed with an accelerometer. Rev Neurol (Paris). 2003;159:786–789[in French]
  36. Hansen BD, Lascelles BD, Keene BW, Adams AK, Thomson AE. Evaluation of an accelerometer for at-home monitoring of spontaneous activity in dogs. Am J Vet Res. 2007;68:468–475
  37. Yamada M, Tokuriki M. Spontaneous activities measured continuously by an accelerometer in beagle dogs housed in a cage. J Vet Med Sci. 2000;62:443–447
  38. Leleu C, Gloria E, Renault G, Barrey E. Analysis of trotter gait on the track by accelerometry and image analysis. Equine Vet J Suppl. 2002;34:344–348
  39. Leleu C, Bariller F, Cotrel C, Barrey E. Reproducibility of a locomotor test for trotter horses. Vet J. 2004;168:160–166
  40. Bartlett RJ, Winand NJ, Secore SL, et al. Mutation segregation and rapid carrier detection of X-linked muscular dystrophy in dogs. Am J Vet Res. 1996;57:650–654
  41. Cooper BJ, Winand NJ, Stedman H, et al. The homologue of the Duchenne locus is defective in X-linked muscular dystrophy of dogs. Nature. 1988;334:154–156
  42. Valentine BA, Winand NJ, Pradhan D, et al. Canine X-linked muscular dystrophy as an animal model of Duchenne muscular dystrophy: a review. Am J Med Genet. 1992;42:352–356
  43. Ambrosio CE, Fadel L, Gaiad TP, et al. Identification of three distinguishable phenotypes in golden retriever muscular dystrophy. Genet Mol Res. 2009;8:389–396
  44. Ambrosio CE, Valadares MC, Zucconi E, et al. Ringo, a Golden Retriever Muscular Dystrophy (GRMD) dog with absent dystrophin but normal strength. Neuromuscul Disord. 2008;18:892–893
  45. Dingwell JB, Cavanagh PR. Increased variability of continuous overground walking in neuropathic patients is only indirectly related to sensory loss. Gait Posture. 2001;14:1–10
  46. Hausdorff JM, Edelberg HK, Mitchell SL, Goldberger AL, Wei JY. Increased gait unsteadiness in community-dwelling elderly fallers. Arch Phys Med Rehabil. 1997;78:278–283
  47. Pele M, Tiret L, Kessler JL, Blot S, Panthier JJ. SINE exonic insertion in the PTPLA gene leads to multiple splicing defects and segregates with the autosomal recessive centronuclear myopathy in dogs. Hum Mol Genet. 2005;14:1417–1427
  48. Lee H-K, Lee K-J, Cho S-P, You J. Computational method and feasibility of detecting the whole body centre of gravity using an accelerometric device. Electron Lett. 2007;43:1068–1070

PII: S0960-8966(09)00578-1

doi: 10.1016/j.nmd.2009.07.014

Neuromuscular Disorders
Volume 19, Issue 11 , Pages 788-796 , November 2009