Neuromuscular Disorders
Volume 18, Issue 1 , Pages 17-18 , January 2008

Mesenchymal stem cells from umbilical cord: Do not discard the cord!

  • Mariane Secco

      Affiliations

    • Human Genome Research Center, Department of Genetic and Evolutive Biology, University of São Paulo, São Paulo, SP, Brazil
    • These authors contributed equally to this work.
    • ,
  • Eder Zucconi

      Affiliations

    • Human Genome Research Center, Department of Genetic and Evolutive Biology, University of São Paulo, São Paulo, SP, Brazil
    • These authors contributed equally to this work.
    • ,
  • Natassia M. Vieira

      Affiliations

    • Human Genome Research Center, Department of Genetic and Evolutive Biology, University of São Paulo, São Paulo, SP, Brazil
    • ,
  • Luciana L.Q. Fogaça

      Affiliations

    • Human Genome Research Center, Department of Genetic and Evolutive Biology, University of São Paulo, São Paulo, SP, Brazil
    • ,
  • Antonia Cerqueira

      Affiliations

    • Human Genome Research Center, Department of Genetic and Evolutive Biology, University of São Paulo, São Paulo, SP, Brazil
    • ,
  • Maria Denise F. Carvalho

      Affiliations

    • Human Genome Research Center, Department of Genetic and Evolutive Biology, University of São Paulo, São Paulo, SP, Brazil
    • ,
  • Tatiana Jazedje

      Affiliations

    • Human Genome Research Center, Department of Genetic and Evolutive Biology, University of São Paulo, São Paulo, SP, Brazil
    • ,
  • Oswaldo K. Okamoto

      Affiliations

    • Department of Neurology and Neurocirurgy, Federal University of São Paulo, São Paulo, SP, Brazil
    • ,
  • Alysson R. Muotri

      Affiliations

    • Laboratory of Genetic, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    • ,
  • Mayana Zatz

      Affiliations

    • Human Genome Research Center, Department of Genetic and Evolutive Biology, University of São Paulo, São Paulo, SP, Brazil
    • Corresponding Author InformationCorresponding author.

Received 27 October 2007 ,Accepted 19 November 2007.

References 

  1. The umbilical cord blood banking Richard Branson’s way. Lancet 2007;369:437.
  2. Secco M, Zucconi E, Vieira NM, et al. Multipotent stem cells from umbilical cord: cord is richer than blood!. Stem Cells. 2007;
  3. Cohena Y, Nagler A. Hematopoietic stem-cell transplantation using umbilical cord blood. Leuk Lymphoma. 2003;44:1287–1299
  4. Ooi J. The efficacy of unrelated cord blood transplantation for adult myelodysplastic syndrome. Leuk Lymphoma. 2006;47:599–602
  5. Laughlin MJ, Barker J, Bamback B, et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med. 2001;344:1815–1822
  6. Hayani A, Lampeter E, Viswanatha D, Morgan D, Salvi SN. First report of autologous cord blood transplantation in the treatment of a child with leukemia. Pediatrics. 2007;119:296–300
  7. Lee OK, Kuo TK, Chen WM, Lee KD, Hsieh SL, Chen TH. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood. 2004;103:1669–1675
  8. Erices A, Conget P, Minguell JJ. Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol. 2000;109:235–242
  9. Goodwin HS, Bicknese AR, Chien SN, Bogucki BD, Quinn CO, Wall DA. Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat and neural markers. Biol Blood Marrow Transplant. 2001;7:581–588
  10. Bieback K, Kern S, Kluter H, Eichler H. Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. Stem Cells. 2004;22:625–634
  11. Romanov YA, Svintsitskaya VA, Smirnov VN. Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord. Stem Cells. 2003;21:105–110
  12. Mareschi K, Biasin E, Piacibello W, Aglietta M, Madon E, Fagioli F. Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood. Haematologica. 2001;86:1099–1100
  13. Wexler SA, Donaldson C, Denning-Kendall P, Rice C, Bradley B, Hows JM. Adult bone marrow is a rich source of human mesenchymal ‘stem’ cells but umbilical cord and mobilized adult blood are not. Br J Haematol. 2003;121:368–374
  14. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13:4279–4295
  15. Gang EJ, Jeong JA, Hong SH, et al. Skeletal myogenic differentiation of mesenchymal stem cells isolated from human umbilical cord blood. Stem Cells. 2004;22:617–624
  16. Karahuseyinoglu S, Cinar O, Kilic E, et al. Biology of the stem cells in human umbilical cord stroma: in situ and in vitro surveys. Stem Cells. 2007;25:319–331
  17. Kern S, Eichler H, Stoeve J, Kluter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006;24:1294–1301
  18. Mueller SM, Glowacki J. Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges. J Cell Biochem. 2001;82:583–590
  19. Stenderup K, Justuesen J, Clausen C, Kassem M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone. 2003;33:919–926
  20. Wang HS, Hung SC, Peng ST, et al. Mesenchymal stem cells in the Wharton’s jelly of the human umbilical cord. Stem Cells. 2004;22:1330–1337
  21. Sarugaser R, Lickorish D, Baksh D, Hosseini M, Davies JE. Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors. Stem Cells. 2005;23:220–229
  22. Tondreau T, Meuleman N, Delforge A, et al. Mesenchymal stem cells derived from CD133-positive cells in mobilized peripheral blood and cord blood: proliferation, Oct4 expression, and plasticity. Stem Cells. 2005;23:1105–1112

PII: S0960-8966(07)00763-8

doi: 10.1016/j.nmd.2007.11.003

Neuromuscular Disorders
Volume 18, Issue 1 , Pages 17-18 , January 2008

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