Neuromuscular Disorders
Volume 18, Issue 1 , Pages 19-26, January 2008

Reliability of clinical outcome measures in Charcot-Marie-Tooth disease

  • A. Solari

      Affiliations

    • Neuroepidemiology Unit, IRCCS Foundation, “C. Besta” Neurological Institute, Via Celoria 11, 20133 Milan, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 02 2394 2391; fax: +39 02 7060 6233.
    • ,
  • M. Laurà

      Affiliations

    • Division of Biochemistry and Genetics, IRCCS Foundation, “C. Besta” Neurological Institute, Milan, Italy
    • ,
  • E. Salsano

      Affiliations

    • Division of Biochemistry and Genetics, IRCCS Foundation, “C. Besta” Neurological Institute, Milan, Italy
    • ,
  • D. Radice

      Affiliations

    • Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
    • ,
  • D. Pareyson

      Affiliations

    • Division of Biochemistry and Genetics, IRCCS Foundation, “C. Besta” Neurological Institute, Milan, Italy
    • ,
  • On behalf of the CMT-TRIAAL Study Group

      Affiliations

    • See Appendix B.

Received 12 July 2007; accepted 6 September 2007.

Abstract 

We assessed inter- and intra-rater reliability of outcome measures in Charcot-Marie-Tooth disease (CMT) patients. In 40 CMT patients, we assessed reliability of Overall Neuropathy Limitations Scale (ONLS), 10-m timed walk (T10MW), 9-hole-peg test (9-HPT), maximal voluntary isometric contraction (MVIC) of arm (elbow flexion, hand-grip, and three-point pinch) and leg (knee extension, foot dorsiflexion/plantar flexion). Reliability was substantial for ONLS, excellent for T10MW and 9-HPT. For MVIC, inter and intra-rater reliability was excellent for hand contractions; for leg contractions, intra-rater agreement was moderate to substantial, whereas inter-rater agreement was poor.

An ad hoc device was produced to immobilize the foot and MVIC reliability was re-assessed in 26 CMT patients, resulting in excellent inter-rater and intra-rater reliability for foot dorsiflexion, and clear inter-rater improvement for foot plantar flexion.

All outcome measures appear adequate for CMT assessment. Use of an immobilization device improves foot MVIC reliability, preventing biased findings in patients with greater strength.

Keywords: Reliability, Outcome measures, Randomised clinical trial, Charcot-Marie-Tooth disease

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PII: S0960-8966(07)00723-7

doi:10.1016/j.nmd.2007.09.006

Neuromuscular Disorders
Volume 18, Issue 1 , Pages 19-26, January 2008

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