Neuromuscular Disorders
Volume 18, Issue 1 , Pages 74-80 , January 2008

Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats

  • Domenico Tricarico

      Affiliations

    • Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, via Orabona n° 4, 70120 Bari, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 0805442802; fax:+39 0805442801.
    • ,
  • Antonietta Mele

      Affiliations

    • Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, via Orabona n° 4, 70120 Bari, Italy
    • ,
  • Birgit Liss

      Affiliations

    • Department of General Physiology, Molecular Neurophysiology, University of Ulm, Albert Einsteinalle 11, 89081 Ulm, Germany
    • ,
  • Frances M. Ashcroft

      Affiliations

    • University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    • ,
  • Andrew L. Lundquist

      Affiliations

    • Division of Genetic Medicine, Department of Medicine, Vanderbilt University, 529 Light Hall, Nashville, TN 37232-0275, USA
    • ,
  • Reshma R. Desai

      Affiliations

    • Division of Genetic Medicine, Department of Medicine, Vanderbilt University, 529 Light Hall, Nashville, TN 37232-0275, USA
    • ,
  • Alfred L. George Jr.

      Affiliations

    • Division of Genetic Medicine, Department of Medicine, Vanderbilt University, 529 Light Hall, Nashville, TN 37232-0275, USA
    • ,
  • Diana Conte Camerino

      Affiliations

    • Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, via Orabona n° 4, 70120 Bari, Italy

Received 18 January 2007 ,Revised 17 May 2007 ,Accepted 25 July 2007.

References 

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  9. Tricarico D, Mele A, Lundquist AL, et al. Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties. Proc Nat Acad Sci USA. 2006;103:1118–1123(Epub 2006)
  10. Tricarico D, Pierno S, Mallamaci R, et al. The biophysical and pharmacological characteristics of skeletal muscle KATP channels are modified in K+ depleted rat, an animal model of hypokalemic periodic paralysis. Mol Pharmacol. 1998;54:197–206
  11. Tricarico D, Capriulo R, Conte Camerino D. Insulin modulation of ATP-sensitive K+channel of rat skeletal muscle is impaired in the hypokalemic state. Pflugers Archiv. 1998;437:235–240
  12. Ruff RL. Insulin acts in hypokalemic periodic paralysis by reducing inward rectifier K+ current. Neurology. 1999;53:1556–1563
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PII: S0960-8966(07)00684-0

doi: 10.1016/j.nmd.2007.07.009

Neuromuscular Disorders
Volume 18, Issue 1 , Pages 74-80 , January 2008

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