Neuromuscular Disorders
Volume 18, Issue 1 , Pages 68-70 , January 2008

A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy

  • F.L. Conforti

      Affiliations

    • Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    • ,
  • T. Sprovieri

      Affiliations

    • Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    • ,
  • R. Mazzei

      Affiliations

    • Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    • ,
  • C. Ungaro

      Affiliations

    • Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    • ,
  • V. La Bella

      Affiliations

    • Department of Neurology and Psychiatry, University of Palermo, Palermo, Italy
    • ,
  • A. Tessitore

      Affiliations

    • Second Division of Neurology, Second University of Naples, Naples, Italy
    • ,
  • A. Patitucci

      Affiliations

    • Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    • ,
  • A. Magariello

      Affiliations

    • Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    • ,
  • A.L. Gabriele

      Affiliations

    • Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    • ,
  • G. Tedeschi

      Affiliations

    • Second Division of Neurology, Second University of Naples, Naples, Italy
    • ,
  • I.L. Simone

      Affiliations

    • Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • G. Majorana

      Affiliations

    • Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
    • ,
  • P. Valentino

      Affiliations

    • Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    • ,
  • F. Condino

      Affiliations

    • Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    • ,
  • F. Bono

      Affiliations

    • Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    • ,
  • M.R. Monsurrò

      Affiliations

    • Second Division of Neurology, Second University of Naples, Naples, Italy
    • ,
  • M. Muglia

      Affiliations

    • Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    • ,
  • A. Quattrone

      Affiliations

    • Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    • Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    • Corresponding Author InformationCorresponding author. Address: Institute of Neurology, University Magna Graecia, Campus Universitario, Viale Europa, 88100 Germaneto, Catanzaro, Italy. Tel.: +39 0961 3697075; fax: +39 0961 3697177.

Received 5 June 2007 ,Revised 12 July 2007 ,Accepted 16 July 2007.

References 

  1. Greenway MJ, Andersen PM, Russ C, et al. ANG mutations segregate with familial and ’sporadic’ amyotrophic lateral sclerosis. Nat Genet. 2006;38(4):411–413
  2. Lambrechts D, Lafuste P, Carmeliet P, Conway EM. Another angiogenic gene linked to amyotrophic lateral sclerosis. Trends Mol Med. 2006;12(8):345–347
  3. Greenway MJ, Alexander MD, Ennis S, et al. A novel candidate region for ALS on chromosome 14q11.2. Neurology. 2004;63(10):1936–1938
  4. Corrado L, Battistini S, Penco S, et al. Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population. J Neurol Sci. 2007;258(1–2):123–127
  5. Kiraly O, Boulling A, Witt H, et al. Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. Hum Mutat. 2007;28(5):469–476
  6. Gass J, Cannon A, Mackenzie IR, et al. Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. Hum Mol Genet. 2006;15(20):2988–3001

PII: S0960-8966(07)00676-1

doi: 10.1016/j.nmd.2007.07.003

Neuromuscular Disorders
Volume 18, Issue 1 , Pages 68-70 , January 2008

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