Neuromuscular Disorders
Volume 16, Issue 6 , Pages 394-395 , June 2006

Demyelinating polyneuropathy in Leber hereditary optic neuropathy

  • H.J. Gilhuis

      Affiliations

    • Department of Neurology and Neurophysiology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 243618860; fax: +31 243541122.
    • ,
  • H.J. Schelhaas

      Affiliations

    • Department of Neurology and Neurophysiology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    • ,
  • J.R.M. Cruysberg

      Affiliations

    • Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • M.J. Zwarts

      Affiliations

    • Department of Neurology and Neurophysiology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands

Received 21 October 2005 ,Revised 24 January 2006 ,Accepted 6 March 2006.

References 

  1. Riordan-Eva P, Sanders MD, Govan GG, Sweeney MG, Da Costa J, Harding AE. The clinical features of Leber's hereditary optic neuropathy defined by the presence of a pathogenic mitochondrial DNA mutation. Brain. 1995;118:319–337
  2. Nikoskelainen EK, Marttila RJ, Huoponen K, et al. Leber's ‘plus’: neurological abnormalities in patients with Leber's hereditary optic neuropathy. J Neurol Neurosurg Psychiatry. 1995;59:160–164
  3. Kovacs GG, Hoftberger R, Majtenyi K, et al. Neuropathology of white matter disease in Leber's hereditary optic neuropathy. Brain. 2005;128:35–41
  4. Jansen PHP, van der Knaap MS, de Coo IFM. Leber's hereditary optic neuropathy with the 11778 mtDNA mutation and white matter disease resembling multiple sclerosis: clinical, MRI and MRS findings. J Neurol Sci. 1996;135:176–180
  5. Lev D, Yanoov-Sharav M, Watemberg N, Leshinsky-Silver E, Lerman-Sagie T. White matter abnormalities in Leber's hereditary optic neuropathy due to the 3460 mitochondrial DNA. Eur J Paediatr Neurol. 2002;6:121–123
  6. Kwittken J, Barest HD. The neuropathology of hereditary optic atrophy (Leber's disease); the first complete anatomic study. Am J Pathol. 1958;34:185–207
  7. Carelli V, Ross-Cisneros FN, Sadun AA. Mitochondrial dysfunction as a cause of optic neuropathies. Prog Retin Eye Res. 2004;23:53–89

PII: S0960-8966(06)00092-7

doi: 10.1016/j.nmd.2006.03.006

Neuromuscular Disorders
Volume 16, Issue 6 , Pages 394-395 , June 2006

Article Tools